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But despite the dirt and grime you should be pretty safe here, particularly if you stay in the right areas.
The El Conde in Zona Colonial is probably the best spot for a first time visitor.
It is the main touristy area which is a good party and nightlife hot spot, has good shopping, and is probably the best and safest place to try and pick up single Santo Domingo girls.
Try and book a hotel in the Zona Colonial area, but make sure you inquire if they will allow visitors.
Hotels often change their policies on this so you need to contact them first to make sure, otherwise you might be in some trouble later on.
Getting a place off Air Bnb might be better if you can find a good one.